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Research & Science



Ketamine has potential therapeutic role in adolescents with treatment-resistant depression

Ketamine for Pain Management, Treatment of Depression

Medical Daily: Ketamine Helps Patients With Bipolar Disorder, Depression, But Works Differently Among The Two by S. Castillo

National Institute of Mental Health: Ketamine Lifts Depression via a Byproduct of its Metabolism

WebMD: Ketamine: The Future of Depression Treatment? by Matt McMillen

National Institute of Mental Health: Rapid Agent Restores Pleasure-seeking Ahead of Other Antidepressant Action

VICE: I Used Ketamine to Treat My Depression by Brent Miles & Troy Farah

The Journal of the American Society of Anesthesiologists, Inc.: Ketamine Metabolomics in the Treatment of Major Depression by Monique van Velzen, PhD & Albert Dahan, MD, PhD

Suicidal Ideation

Medical News Today: Ketamine ‘rapid and effective’ for reducing suicidal thoughts by Honor Whiteman

J Clin Psychiatry: Rapid Resolution of Suicidal Ideation after a Single Infusion of an NMDA Antagonist in Patients with Treatment-Resistant Major Depressive Disorder by Nancy DiazGranados, MD et. al.

Digital Access to Scholarship at Harvard: Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression by Rebecca B. Price, Matthew K. Nock, et al

The International Journal of Neuropsychopharmacology: A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department by Gregory Luke Larkin & Annette L. Beautrais

Postpartum Depression

Medscape: Postpartum Depression by Saju Joy, MD

Bipolar Depression

Medical Daily: Ketamine Helps Patients With Bipolar Disorder, Depression, But Works Differently Among The Two by Stephanie Castillo

Treatment-resistant Depression

The American Journal of Psychiatry: A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression by Jaskaran B. Singh, MD, Maggie Fedgchin, PharmD, et al



National Pain Report: This Could Be Big: Intravenous Ketamine for Fibromyalgia by Ginevra Liptan, MD

PR Newswire: Breakthrough Fibromyalgia and CRPS treatment with IV Ketamine by Dr. Ashraf Hanna at the Florida Spine Institute

PubMed: Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine by J. Sörensen, A. Bengtsson, et al

PubMed: Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients by T. Graven-Nielsen, S. Kendall Aspegren, et al

PubMed: Intravenous infusions in chronic pain management by B. Kosharskyy, W. Almonte, et al



Columbia University Medical Center: PTSD Symptoms May Be Prevented With Ketamine

The Journal of The American Medical Association: Ketamine Effective in Treating PTSD by Anita Slomski

Medscape: Ketamine: New Potential as Rapid PTSD Treatment by Caroline Cassels

JAMA Psychiatry: Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder by Adriana Feder, MD, Michael K. Parides, PhD, et al

Psych Congress Network: Ketamine Significantly Improves PTSD Symptoms by Jolynn Tumolo



Ketamine: Fresh hope for the treatment of OCD

Researcher investigates hallucinogen as potential OCD treatment

Grant JE, Fineberg N, van Ameringen M, et al. New treatment models for compulsive disorders. Eur Neuropsychopharmacol. 2016;26(5):877-884.

Bloch MH, Wasylink S, Landeros-Weisenberger A, et al. Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2012; 72(11):964-970.

Rodriguez CI, Kegeles LS, Levinson A, et al. Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacology. 2013;38(12):2475-2483.



Correll GE, Maleki J, Gracely EJ, Muir JJ, Harbut RE. Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome. Pain Med. 2004 Sep. 5(3):263-75.

Kiefer RT, Rohr P, Ploppa A, Dieterich HJ, Grothusen J, Koffler S, et al. Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. Pain Med. 2008 Nov. 9(8):1173-201.

Sigtermans MJ, van Hilten JJ, Bauer MC, Arbous MS, Marinus J, Sarton EY. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain. 2009 Oct. 145(3):304-11.

Schwartzman RJ, Alexander GM, Grothusen JR, Paylor T, Reichenberger E, Perreault M. Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study. Pain. 2009 Dec 15. 147(1-3):107-15.



PainWeek 2014: For Refractory Migraine, Consider Ketamine by Debra Hughes, MS

The Journal of Pain: Official Journal of the American Pain Society: IV ketamine treatment for multiple headache and pain disorders by J. Krusz, J. Cagle, and V. Scott-Krusz

WebMD: Ketamine May Treat Migraine, Chronic Pain by Pauline Anderson

Medscape: Ketamine May Be Useful in Migraine, Chronic Pain by Pauline Anderson


Substance Abuse

Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review

Another Round of Research Shows Ketamine May Help Alcoholism

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